We've got 30 cabinet doors in our kitchen (I know because I painted them all with multiple coats in 2009- ugg!). That's a lot! I love the idea of taking a couple of them off to mix things up a bit. Here's what others have done:
The work load is minimal: pop off the door, fill in the hinge holes with dry wall repair, sand, and touch up with paint. If you've got wooden cabinets, just leave the holes or find a matching wood filler.